Method of preparing stable sterile ampoules of crystalline cephalosporins for parenteral administration
US4104391A · kind A · utility
6Cited by
3References
11Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Feb 9, 1977 |
| Grant date | Aug 1, 1978 |
| Priority date | — |
| Expiry date | Feb 9, 1997 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K31/545
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Sterile, essentially crystalline cephalosporins for parenteral administration are prepared by a freeze-drying process wherein, after rapidly cooling a solution of such cephalosporins to at least -15.degree. C. in no more than 3 hours, the frozen solution is held between about <0.degree. C. and about -10.degree. C. until the nucleation of the cephalosporin is substantially complete before subjecting said frozen solution to a high vacuum and a moderate amount of heat to sublime the water therefrom.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.