Crystallization process for cefazolin sodium
US4104470A · kind A · utility
3Cited by
1References
7Claims
0Family size
Assignee
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Key dates
| Filing date | Jun 3, 1977 |
| Grant date | Aug 1, 1978 |
| Priority date | — |
| Expiry date | Jun 3, 1997 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D501/36
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The cephalosporin antibiotic, cefazolin sodium, is provided in the monohydrate crystalline form substantially free of other crystalline forms via addition of a concentrated solution of cefazolin acid in a water-miscible organic solvent such as DMAC to a sodium cation donor solution, e.g., sodium acetate in ethanol, wherein said sodium cation donor solution contains water in an amount sufficient to constitute 3-7 percent by volume of the mixed solutions.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.