Production of N-substituted 2-carbamoyl phosphinic acids

US4105689A · kind A · utility

Assignee

• Hoechst GmbH · DE

Inventors

• Eberhard Auer · Lechenich, DE
• Alexander Ohorodnik · Lechenich, DE
• Paul Stutzke · Brühl, DE

Key dates

• Filing date: Oct 25, 1977
• Grant date: Aug 8, 1978
• Expiry date: Oct 25, 1997

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F9/301
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Production of N-substituted 2-carbamoyl phosphinic acids of the general formula: ##STR1## in which R.sup.1 stands for an alkyl group having 1 to 4 carbon atoms or an aryl group; R.sup.2 and R.sup.3 stand independently of each other for an alkyl group having 1 to 4 carbon atoms, an aryl group or a hydrogen atom; R.sup.4 stands for an alkyl group having 1 to 18 carbon atoms, an aryl group or a hydrogen atom; and R.sup.5 stands for an alkyl group having 1 to 18 carbon atoms or an aryl group. More specifically, a 2-chloroformyl phosphinic acid chloride of the general formula ##STR2## is reacted at 120.degree. to 170.degree. C with an amine of the general formula ##STR3## and resulting N-substituted 2-carbamoyl phosphinic acid chloride of the general formula ##STR4## the latter compound being obtained while hydrogen chloride is split off, is hydrolyzed with water.