Hydantoin compounds and methods of use thereof
US4105774A · kind A · utility
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Key dates
| Filing date | Jul 28, 1975 |
| Grant date | Aug 8, 1978 |
| Priority date | — |
| Expiry date | Jul 28, 1995 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D233/74
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Hydantoin derivatives of varying lipophilic character were prepared as nigen mustard carriers for CNS anti-tumor evaluation in transplanted mouse tumor test systems. Activity was studied in the murine ependymoblastoma brain tumor system. Multiple cures were observed for three of the four analogs examined. The compounds were also active in the intraperitoneal leukemia L1210 and P388 systems as well as in B16 melanoma and Lewis lung carcinoma.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.