Certain pleuromulilin ester derivatives
US4107164A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jan 10, 1977 |
| Grant date | Aug 15, 1978 |
| Priority date | — |
| Expiry date | Jan 10, 1997 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C323/25
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
This invention relates to new pleuromutilins of the formula: ##STR1## wherein EITHER PA1 R.sub.1 is ethyl or vinyl, PA1 N is an integer from 2 to 5, PA1 X is sulphur, a group ##STR2## or a group =N--R.sub.4 .sup.I, wherein Wherein PA1 Either Y and Z are both sulphur, or PA1 One of Y and Z is oxygen and the other is sulphur, and PA1 R.sub.4.sup.i is hydrogen or a group of the formula: ##STR3## wherein R.sub.1 is as defined above, PA1 Each of PA1 R.sub.2 and R.sub.3 is alkyl of 1 to 10 carbon atoms, or PA1 R.sub.2 and R.sub.3 together with the nitrogen atom form a heterocycle of 5 to 7 ring members, And pharmaceutically acceptable acid addition salts and quaternary salts thereof. Processes for the preparation of such compounds are described. The compounds are antibiotics with an antibacterial effect.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.