Quinoline-3-carboxamides
US4107310A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Feb 7, 1977 |
| Grant date | Aug 15, 1978 |
| Priority date | — |
| Expiry date | Feb 7, 1997 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07F3/02
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Novel quinoline-3-carboxamides of the formula ##STR1## wherein R.sub.1 is in the 5,6,7 or 8-position and is selected from the group consisting of hydrogen, halogen, --CF.sub.3, --OCF.sub.3, --SCF.sub.3, straight chain alkyl of 1 to 4 carbon atoms, branched alkyl of 3 to 5 carbon atoms and alkoxy of 1 to 4 carbon atoms, R.sub.2 is selected from the group consisting of hydrogen and methyl, R.sub.3 is selected from the group consisting of thiazolyl, 4,5-dihydrothiazolyl, pyridinyl, oxazolyl and imidazolyl and R.sub.4 is selected from the group consisting of hydrogen, hydroxyl, alkyl of 1 to 4 carbon atoms, phenyl and benzyl with the proviso that when R.sub.1 is in the 7 or 8-position and is halogen, --CH.sub.3, --OCF.sub.3 or --SCF.sub.3 and R.sub.4 is hydrogen, R.sub.3 is not thiazolyl, pyridinyl or oxazolyl and the non-toxic, pharmaceutically acceptable acid addition salts when R.sub.3 is imidazolyl or 4,5-dihydrothiazolyl having analgesic activity and their preparation and novel intermediates therefore.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.