Process for preparing arylalkanoic acid derivatives
US4107439A · kind A · utility
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18Claims
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Key dates
| Filing date | Jun 16, 1976 |
| Grant date | Aug 15, 1978 |
| Priority date | — |
| Expiry date | Jun 16, 1996 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C63/72
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
2-Aryl-C.sub.3 to C.sub.6 -alkanoate esters are prepared economically by reacting an enol ether of an aryl alkyl ketone with a trivalent thallium salt in an organic solvent. The ester intermediate product is then converted to the corresponding 2-aryl-C.sub.3 to C.sub.6 -alkanoic acid or salt thereof. The aryl group is selected so the resulting acid product will be a useful compound such as an anti-inflammatory, analgesic and anti-pyretic drug or agriculturally useful product. Examples of drug acids which can be made by this process include ibuprofen, flurbiprofen, fenoprofen and naproxen and the like.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.