Compounds of ergolene and ergoline structure and method for the preparation thereof
US4108855A · kind A · utility
14Cited by
1References
10Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Mar 2, 1977 |
| Grant date | Aug 22, 1978 |
| Priority date | — |
| Expiry date | Mar 2, 1997 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02P20/55
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention relates to a novel compound of the formula ##STR1## and the pharmaceuticlly acceptable acid addition salts thereof, wherein R stands for a hydrogen atom or methyl group, x y designates a ##STR2## Q is a hydrogen atom or a benzyloxycarbonyl- or N-tert.-butyloxycarbonyl protective group, and R.sub.1 is the side chain of a natural .alpha.-amino acid selected from the group consisting of Arg--, Tryp-13 , Phe--, Ser--, Leu--, Val--, Meth--, Tyr--, His-- or Prol---side-chain. The compounds according to the invention possess antiserotonin and hypotensive effects and act upon the central nervous system.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.