Immunological reagent employing radioactive and other tracers
US4108972A · kind A · utility
Inventor
Key dates
| Filing date | Nov 12, 1975 |
| Grant date | Aug 22, 1978 |
| Priority date | — |
| Expiry date | Nov 12, 1995 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S436/808
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A broad new class of reagents permits extremely sensitive and specific assay for, or chemical separation of, a broad range of biological and nonbiological substances. Each reagent consists of a suspension of microscopic carrier material particles, each particle bearing (1) tracer material - fluorescent, radioactive or otherwise - and (2) a coating of biological homologue, that is, antibody, antigen, or portions or equivalents thereof, for the substance whose assay is desired. The latter substance if introduced into the suspension links the particles together in pairs or clumps, which may be sensitively and accurately detected by monitoring the tracer. The carrier is preferably partially hydrolyzed polyacrylamide resin, or in appropriate applications acrylic acid and other derivatives thereof, and other polymers including agar, and the coupling effected by covalent bonding. Other embodiments, including various mechanical forms of carrier, for greater ease of handling and separation, are also described.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.