Cyclic hexapeptides
US4108987A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Sep 12, 1977 |
| Grant date | Aug 22, 1978 |
| Priority date | — |
| Expiry date | Sep 12, 1997 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S930/27
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Synthetic novel cyclic hexapeptides having the structure: PA1 Cyclo[(N-alkylamino acid)-X-(N-alkylamino acid)'-X-(N-alkylamino acid)"-X] wherein (N-alkylamino acid), (N-alkylamino acid)' and (N-alkylamino acid)" have the structure: ##STR1## wherein R.sup.1 is a lower alkyl group having 1 to 3 carbon atoms and R.sup.2 is hydrogen and methyl or R.sup.1 and R.sup.2 are --CH.sub.2 --N, n being an integer 2 or 3, and form a 4- or 5- membered ring; and X is D- or L-Ala, D- or L-Phe, D- or L-Leu, D- or L-p-halophenylalanyl or D- or L-p-nitrophenylalanyl, with the proviso that when R.sup.1 is methyl and R.sup.2 is hydrogen, X is not D-Ala are prepared. Oral administration of these cyclic peptides improves the digestive efficiency of certain herbivorous animals.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.