3-Oxo-5,6-dihydro-1,2,4-oxadiazines useful as antiandrogenic agents
US4108993A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Oct 5, 1976 |
| Grant date | Aug 22, 1978 |
| Priority date | — |
| Expiry date | Oct 5, 1996 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C323/00
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Antiandrogenic compositions comprising an effective amount of at least one compound of the formula ##STR1## wherein X and Y are individually selected from the group consisting of hydrogen, halogen, --CF.sub.3, --NO.sub.3 and alkylthio of 1 to 4 carbon atoms and R is selected from the group consisting of hydrogen, alkyl of 1 to 6 carbon atoms, phenyl, benzyl and hydroxymethyl and an inert pharmaceutical carrier and a method of inducing antiandrogenic activity in warm-blooded animals as well as novel oxadiazines of formula I with the proviso that when R is other than benzyl or hydroxymethyl at least one of X and Y is alkylthio of 1 to 4 carbon atoms.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.