Patent · US Expired

Lithium pantoate and optically active isomers thereof and process of making the same

US4111987A · kind A · utility

1Cited by

1References

2Claims

0Family size

Assignee

VEB Jenapharm · DE

Inventors

Joachim Schmidt · Schlangen, DE
Christian Weigelt · Jena, DE
Wolfgang Bamberg · Jena, DE
Wolfgang Schneider · Marl, DE

Key dates

Filing date	Mar 16, 1976
Grant date	Sep 5, 1978
Priority date	—
Expiry date	Mar 16, 1996

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07C59/105
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

A process for the resolution of optical isomers of racemic lithium pantoate by selective crystallization from a solution in methanol, ethanol, or other polar solvents, or by electrostatic separation. The optical isomers can be readily converted to optically active pantolactones which are the starting material for the preparation of optically active pantothenic acid and its salt and pantothenyl alcohol. One of the two optical isomers of each of these compounds possesses vitamin activity. The unwanted or inactive optical isomer of lithium pantoate as such is thermally stable and can be racemized by heating in the presence of a basic reacting compound at a temperature between 120.degree. and 180.degree. C to produce a racemic mixture which can then be subjected directly to resolution without conversion to some other derivative in accordance with the processes of the present invention to produce the desired or active optical isomer.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.