Pyrazol-5-ones

US4112227A · kind A · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Eike Moller · Wuppertal, DE
• Karl Meng
• Egbert Wehinger
• Harald Horstmann

Key dates

• Filing date: Jan 24, 1975
• Grant date: Sep 5, 1978
• Expiry date: Jan 24, 1995

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D231/24
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

1-Substituted pyrazole-5-ones of the formula ##STR1## and pharmaceutically acceptable, nontoxic salts thereof, wherein R is hydrogen or amino; PA1 R.sup.1 is hydrogen, alkyl, alkenyl, unsubstituted or substituted aryl or unsubstituted or substituted aralky; PA1 X is PA2 (a) ethylene, ethylene wherein 1 hydrogen atom on one of the carbon atoms is substituted by alkyl of 1 to 4 carbon atoms, ethylene wherein 1 hydrogen atom on each of the two carbon atoms is substituted by alkyl of 1 to 4 carbon atoms or said ethylene which is linked to R.sup.2 via an oxygen or sulphur atom; PA2 (b) propenyl, propenyl wherein 1 hydrogen atom on one, two or three of the carbon atoms is substituted by alkyl of 1 to 4 carbon atoms, said propenyl being linked to the N.sup.1 atom of the pyrazol ring via its methylene moiety; or PA2 (c) methylene; PA2 provided that when X is methylene, R.sup.1 is not hydrogen if R is amino; PA1 R.sup.2 is aryl unsubstituted or substituted by: PA2 (a) 1 or 2 of the same or different substituents selected from the group consisting of halogen, trifluoromethyl, alkyl of 1 to 8 carbon atoms, alkenyl of 2 to 8 carbon atoms and lower alkoxy; PA2 (b) cycloalkyl of 5, 6 or 7 carbon…