Process for preparing 6-aminopenicillanic acid
US4113566A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Nov 26, 1976 |
| Grant date | Sep 12, 1978 |
| Priority date | — |
| Expiry date | Nov 26, 1996 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S435/873
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A simple and efficient process for the deacylation of penicillins to 6-aminopenicillanic acid in which an aqueous penicillin solution is rapidly recirculated through a shallow bed comprising particulate immobilized penicillin acylase at 15.degree.-45.degree. C and pH 6.5-9.0 until substantial conversion results. PAC BACKGROUND OF THE INVENTION This invention relates to penicillins. More specifically, it relates to the enzymatic deacylation of penicillins to 6-aminopenicillanic acid. 6-Aminopenicillanic acid, commonly referred to as 6-APA, is an intermediate in the manufacture of synthetic penicillins and is prepared among other means by the deacylation of penicillins. This conversion has been effected by both chemical and biochemical techniques. The chemical conversion, as exemplified by U.S. Pat. No. 3,499,909, suffers from being a multi-step process requiring energy-intensive low-temperature conditions and specialized equipment. The biochemical conversion utilizes the enzyme penicillin acylase, or penicillin amidase. In U.S. Pat. No. 3,260,653, the enzyme activity is supplied by certain bacteria or bacterial extracts. This approach is not entirely satisfactory for the industrial …
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.