Method for preparing 17 .alpha.-ester-21-halo pregnanes
US4113680A · kind A · utility
18Cited by
2References
15Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Mar 29, 1976 |
| Grant date | Sep 12, 1978 |
| Priority date | — |
| Expiry date | Mar 29, 1996 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07J7/0085
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
One-step method for preparing 17 .alpha.-ester-21-halo pregnanes by reacting 17 .alpha., 21-cyclic orthoesters of 17 .alpha., 21-dihydroxy pregnanes with a halo compound in the presence of an organic polar solvent, simultaneously resulting in halogenation at 21-position and esterification at 17 .alpha.-position of said 17 .alpha., 21-cyclic orthoesters, the reaction proceeding in a short period of time without, or substantially without, any unfavorable side-reactions.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.