Amino acid derivatives
US4113715A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jan 17, 1977 |
| Grant date | Sep 12, 1978 |
| Priority date | — |
| Expiry date | Jan 17, 1997 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S530/80
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
New substituted acyl derivatives of amino acids which have the general formula ##STR1## are useful as angiotensin converting enzyme inhibitors. PAC SUMMARY OF THE INVENTION This invention relates to new substituted acyl derivatives of amino acids which have the general formula ##STR2## and salts thereof, WHEREIN R is hydroxy or lower alkoxy; R.sub.1 is hydrogen, lower alkanoyl or amino(imino)methyl; R.sub.2 is hydrogen, lower alkyl or phenyl-lower alkylene; R.sub.3 is hydrogen, lower alkanoyl, benzoyl or ##STR3## A is hydrogen, lower alkyl or hydroxy-lower alkylene; B is hydrogen, lower alkyl, phenyl, phenyl-lower alkylene, hydroxy-lower alkylene, hydroxyphenyl-lower alkylene, amino-lower alkylene, guanidino-lower alkylene, mercapto-lower alkylene, lower alkyl-thio-lower alkylene, imidazolyl-lower alkylene, indolyl-lower alkylene, carbamoyl-lower alkylene or carboxy-lower alkylene; OR A and B together form a (CH.sub.2).sub.p bridge which completes a ring of 5 or 6 atoms with the nitrogen and carbon to which they are joined, one carbon optionally bearing a hydroxy group; N IS 0 OR 1; M IS 0, 1, 2, 3 OR 4; AT LEAST ONE OF M AND N IS OTHER THAN 0; AND P IS 3 OR 4. The asterisks denote…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.