Hypoglycemically and hypolipidemically active derivatives of phenyl-alkane-carboxylic acids

US4113871A · kind A · utility

Assignee

• Boehringer Mannheim GmbH · DE

Inventors

• Kurt Stach
• Elmar Bosies · Weinheim, DE
• Ruth Heerdt · Mannheim, DE
• Hans-Frieder Kuhnle · Weinheim, DE
• Felix Helmut Schmidt

Key dates

• Filing date: Apr 8, 1976
• Grant date: Sep 12, 1978
• Expiry date: Apr 8, 1996

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2603/18
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Phenyl-alkane-carboxylic acids of the formula ##STR1## wherein A is an aryl, aralkyl or arylvinyl radical optionally substituted by hydroxy, halogen, trifluoromethyl, alkyl, alkylthio, alkoxy, alkenyloxy, alkoxyalkoxy, alkyl-substituted amino, aryloxy or alkoxy-substituted aryloxy, or is an aryloxyalkyl or arylthioalkyl radical, or a heterocyclic ring system optionally substituted by halogen, alkyl or alkoxy, PA1 Y is a valency bond or an unbranched or branched lower alkylene radical containing up to 3 carbon atoms, PA1 X is a straight or branched, saturated or unsaturated divalent aliphatic hydrocarbon radical containing 2 to 8 carbon atoms, there being at least 2 carbon atoms between the benzene ring and the carboxyl group, and PA1 R is a hydrogen atom or a lower alkyl radical, as well as physiologically compatible salts, esters and amides thereof, exhibit hypoglycaemic and hypolipidaemic activity.