5-Fluorouracil derivatives
US4113949A · kind A · utility
2Cited by
3References
4Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Mar 11, 1976 |
| Grant date | Sep 12, 1978 |
| Priority date | — |
| Expiry date | Mar 11, 1996 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D239/22
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Direct fluorination of uracil and its derivatives, in the presence of an aqueous solvent, by fluorine gas to produce 5-fluorouracil and 5-fluorouracil derivatives is disclosed. Novel compounds produced by the reaction, such as 5,5-difluoro-6-hydroxy-5,6-dihydrouracil are also disclosed. The derivatives of 5-fluorouracil are useful as germicidal agents while 5-fluorouracil itself is a known cancer chemotherapy agent.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.