2,9-Dioxatricyclo [4,3,1,0,3,7] decane derivatives, processes for their preparation and pharmaceutical compositions thereof

US4117148A · kind A · utility

Assignee

• Kali-Chemie Pharma GmbH · DE

Inventors

• Peter W. Thies · Hannover, DE
• Samuel David · Dorval, CA

Key dates

• Filing date: Aug 22, 1977
• Grant date: Sep 26, 1978
• Expiry date: Aug 22, 1997

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D493/08
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

3-AZIDOMETHYL-2,9-DIOXATRICYCLO[4,3,1,0.sup.3,7 ] DECANE DERIVATIVES ARE DISCLOSED WHICH EXHIBIT ANALGESIC, AS WELL AS ANTIPYRETIC AND ANTIPHLOGISTIC PROPERTIES, AND WHICH HAVE THE FORMULA (I) ##STR1## wherein: R.sub.1 represents alkyloxy or aralkyloxy; PA1 One of R.sub.2 and R.sub.3 is hydrogen and the other represents hydroxy, acyloxy or carbamyloxy, or R.sub.2 and R.sub.3 jointly represent oxygen; and, PA1 Y and y' each represent hydrogen or jointly form a bond, As well as pharmaceutical formulations thereof. By reducing the 3-azidomethyl compounds of formula (I), the corresponding 3-aminomethyl compounds are obtained which possess sedative properties and which are valuable intermediates for preparing 3-(mono- or dialkylaminomethyl)-2,9-dioxatricyclo[4,3,1,0.sup.3,7 ] decanes which exhibit sedative and soporific activities.