Deamino derivatives of the kallikrein-trypsin inhibitor

US4118481A · kind A · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Eugen Schnabel · Wuppertal, DE
• Horst D. Schlumberger · Wuppertal, DE
• Gerd Reinhardt · Kelkheim, DE
• Ernst Truscheit · Häger, DE
• Harald Tschesche · Bielefeld, DE

Key dates

• Filing date: Apr 29, 1977
• Grant date: Oct 3, 1978
• Expiry date: Apr 29, 1997

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S930/26
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A demaino kallikrein-trypsin inhibitor obtained from cattle organs is characterized by (a) 0 to 3 lysine residues and/or 3 to 6 arginine residues and/or 1 to 4 tyrosine residues; (b) the 10- and/or 21-tyrosine residues being unsubstituted or substituted by at least one nitro, nitroso or amino in the ortho position relative to the phenolic hydroxy group; and (c) having protease inhibitory activity of BPTI and elastase inhibition activity.