Peptides having gonadoliberin activity and process for their manufacture

US4118483A · kind A · utility

Assignee

• Hoechst GmbH · DE

Inventors

• Wolfgang Konig · Hofheim, DE
• Rolf Geiger · Frankfurt am Main, DE
• Jurgen K. Sandow · Königstein, DE

Key dates

• Filing date: Apr 20, 1977
• Grant date: Oct 3, 1978
• Expiry date: Apr 20, 1997

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S930/13
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A peptide with LH-RH-activity which is a LH-RH-peptide wherein Gly in 6-position is replaced by D-glutaminic-acid which may be N-substituted at the CO-NH.sub.2 moiety, wherein in 10-position Gly-NH.sub.2 may be replaced by a NH-alkyl or NH-cycloalkyl group and/or wherein the amino acids in 4-, 5-, 7- and/or 8-position may be replaced by other amino acids and a process for its manufacture.