Substituted azol-1-ylmethanes

US4118487A · kind A · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Erik Regel
• Wilfried Draber
• Karl H. Buchel · Burscheid, DE
• Manfred Plempel · Haan, DE

Key dates

• Filing date: Dec 5, 1975
• Grant date: Oct 3, 1978
• Expiry date: Dec 5, 1995

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D249/08
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Azol-1-ylmethanes substituted on the methane carbon atom by (a) phenyl or lower alkyl and (b) by a biphenyl-4-yl, 4-phenoxyphenyl, 4-phenylthiophenyl, 4-phenylsulfinylphenyl or 4-phenylsulfonylphenyl group are antimycotic and antibacterial agents. The compounds, of which (biphenyl-4-yl)phenyl-imidazol-1-ylmethane is a typical example, are prepared from the correspondingly substituted carbinol through treatment with thionyl-bis-azole or from the correspondingly substituted methyl halide with the azole or a derivative thereof.