Bronchospasmolytic 1-(p-amino-phenyl)-2-amino-ethanols-(1) and salts

US4119710A · kind A · utility

Assignee

• Boehringer Ingelheim GmbH · DE

Inventors

• Gunther Engelhardt
• Johannes Keck · Zell am Harmersbach, DE
• Gerd Kruger
• Klaus Noll · Cologne, DE
• Helmut Pieper · Lohr am Main, DE

Key dates

• Filing date: Dec 28, 1976
• Grant date: Oct 10, 1978
• Expiry date: Dec 28, 1996

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D263/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Racemic and optically active compounds of the formula ##STR1## wherein R.sub.1 is hydrogen, fluorine, chlorine, bromine, iodine or cyano, PA1 R.sub.2 is fluorine, trifluoromethyl, nitro or cyano, and PA1 R.sub.3 is alkyl of 3 to 5 carbon atoms, hydroxy(alkyl of 3 to 5 carbon atoms), cycloalkyl of 3 to 5 carbon atoms, 1-(3,4-methylenedioxy-phenyl)-2-propyl or 1-(p-hydroxy-phenyl)-2-propyl, And non-toxic, pharmacologically acceptable acid addition salts thereof; the compounds as well as their salts are useful as analgesics, uterospasmolytics, bronchospasmolytics and antispastics for the skeletal musculature, and especially as .beta..sub.2 -receptor mimetics and .beta..sub.1 -receptor blockers.