Alkylsulfonylphenoxypropanolamine therapeutic process
US4119729A · kind A · utility
2Cited by
6References
6Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Oct 27, 1977 |
| Grant date | Oct 10, 1978 |
| Priority date | — |
| Expiry date | Oct 27, 1997 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K31/18
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A new class of phenoxypropanolamine alkylsulfonyl derivatives and methods for their preparation are described. The new compounds possess antiarrhythmic and/or cardioselective .beta.-adrenergic blocking properties and are useful in the treatment of hypertension. Representative embodiments of the invention are 1-(isopropylamino)-3-[4-(methylsulfonyl)-m-tolyloxy]-2-propanol and 3-[4-(methylsulfonyl)-m-tolyloxy]-1-(1-phenoxy-2-propylamino)-2-propanol, the latter compound is particularly outstanding as an antihypertensive.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.