Pharmaceutical composition for inhibiting and blocking cardioselective beta-receptors
US4120978A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Apr 4, 1977 |
| Grant date | Oct 17, 1978 |
| Priority date | — |
| Expiry date | Apr 4, 1997 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D303/22
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Compounds selected from the group consisting of amines of the formula I ##STR1## in which R.sub.1 and R.sub.2 stand for a member selected from lower alkyl, lower alkenyl, cycloalkyl having 4 to 7 ring members, phenyl-lower alkyl, phenyl-lower alkyl substituted in the phenyl residue by a member selected from lower alkyl, lower alkoxy, halogen and trifluoromethyl, lower alkylene, oxa-lower alkylene, aza-lower alkylene and thia-lower alkylene, and one of R.sub.1 and R.sub.2 stands for hydrogen and the other has the above meanings, Ph stands for a member selected from meta- and para-phenylene and meta- and para-phenylene substituted by a member selected from lower alkyl, lower alkenyl, lower alkinyl, mercapto-lower alkyl, hydroxy-lower alkyl, phenyl, cyano, hydrogen, halogen, lower alkoxy, lower alkenyloxy, lower alkinyloxy, mono-, di and trihalogeno-lower alkyl, cycloalkyl having 5 to 7 ring members and phenoxy, and R.sub.3 stands for a member selected from lower alkyl and cycloalkyl having 5 to 7 ring member, and their condensation product with aldehydes and ketones, and their salts are useful as agents for the inhibition of the cardiac .beta.-receptors.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.