Process for preparing trimeric .DELTA..sup.1 -piperideins and trimeric 1-pyrroline

US4123434A · kind A · utility

Assignee

• Hoechst GmbH · DE

Inventors

• Klaus Warning · Eppstein, DE
• Michael Mitzlaff

Key dates

• Filing date: Aug 9, 1977
• Grant date: Oct 31, 1978
• Expiry date: Aug 9, 1997

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D207/12
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Trimeric piperideins and trimeric pyrrolidine are prepared by saponification of 1-acyl-2-alkoxypiperidines or pyrrolidines of the general formula ##STR1## in which n means 2 or 3 R.sub.1 represents hydrogen or a linear or branched C.sub.1 -C.sub.4 alkyl radical and PA1 R.sub.2 represents a linear or branched C.sub.1 -C.sub.4 alkyl radical In aqueous and/or alcoholic solution in known manner in the presence of a strong acid or base and trimerizing the reaction product at a pH equal to or greater than 8. The compounds are valuable intermediates for the manufacture of alkaloids and other pharmaceutically effective substances and N-heterocycles.