Nucleic acid crosslinking agent and affinity inactivation of nucleic acids therewith
US4123610A · kind A · utility
44Cited by
4References
12Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Mar 9, 1977 |
| Grant date | Oct 31, 1978 |
| Priority date | — |
| Expiry date | Mar 9, 1997 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07H21/00
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The crosslinking agent contains an acylhydrazide moiety, through which it is linked to a cytosine residue on the first chain; and an .alpha.-haloketal moiety which, after attachment of the crosslinking agent to the first chain, is hydrolyzed to an .alpha.-haloketone moiety, through which linking is effected to the base-paired guanine residue on the second chain.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.