Process for the large scale production of human growth hormone by serial secondary suspension culture
US4124448A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Apr 9, 1976 |
| Grant date | Nov 7, 1978 |
| Priority date | — |
| Expiry date | Apr 9, 1996 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K14/61
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
A new system of serially culturing human anterior pituitary gland cells in a new nutrient medium to produce large amounts of human growth hormone. Since only human growth hormone can be used to treat growth deficiencies in man, there is a great demand for the hormone, which is in relative short supply since only 2 to 3 mgs. of the human growth hormone can be extracted from one human pituitary gland obtained at autopsy. Using the new system of culture and new nutrient media, the human pituitary cells can be grown in vitro to produce in approximately three weeks, more than 20 times the amount of extractable growth hormone than that which was originally present in the original tissue now used for extracting the 2 to 3 mgs. of the hormone.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.