4-Hydroxy pyrrolidin-2-onyl-amides
US4124594A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Feb 8, 1978 |
| Grant date | Nov 7, 1978 |
| Priority date | — |
| Expiry date | Feb 8, 1998 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P25/00
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Pyrrolidine derivatives of the formula ##STR1## are prepared from .gamma.-amino-.beta.-hydroxybutyric acid which, after reaction with a silylating agent, is reacted, in the presence of an acid acceptor, with a halogen derivative of an ester of an aliphatic acid and then cyclized to give the corresponding N-alkoxy-carbonylalkyl derivative which is converted into the corresponding amide by treatment with ammonia or with a mono- or di-substituted amine. The compounds produced by the present invention improve learning memory and display a protecting effect against the E.E.G. consequence of an overdose of barbituates and against the reduced performance following brain damage (e.g. cerebral edema).
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.