7.alpha.-Halogeno-3,20-dioxo-1,4-pregnadienes, methods for their manufacture, their use as anti-inflammatory agents, and pharmaceutical formulations useful therefor
US4124707A · kind A · utility
15Cited by
1References
29Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Nov 7, 1977 |
| Grant date | Nov 7, 1978 |
| Priority date | — |
| Expiry date | Nov 7, 1997 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07J71/0031
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Novel 3,20-dioxo-7.alpha.-halogeno-1,4-pregnadienes are described and their use as anti-inflammatory agents. Preferred are 7.alpha.-bromo- and 7.alpha.-chloro- derivatives, particularly 7.alpha.-bromo- and 7.alpha.-chloro-1,4-pregnadienes-11.beta.,17.alpha.,21-triol-3,20-dione 17,21-dihydrocarboncarboxylates, the 16-methyl and 16-methylene derivatives thereof being particularly valuable as topical anti-inflammatory agents.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.