5-Fluorouracil derivatives
US4124765A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Sep 28, 1976 |
| Grant date | Nov 7, 1978 |
| Priority date | — |
| Expiry date | Sep 28, 1996 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D239/553
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
5-Fluorouracil derivatives and a process for their preparation are provided. The 5-fluorouracil derivatives according to the invention have the general formula: ##STR1## R.sub.1 and R.sub.2 are the same or different and are hydrogen or ##STR2## with the proviso that both R.sub.1 and R.sub.2 are not hydrogen at the same time. A.sub.1, A.sub.2 and A.sub.3 are independently selected from hydrogen, and optionally substituted alkoxy and phenyloxy; at least one of A.sub.1, A.sub.2 and A.sub.3 being other than hydrogen. The 5-fluorouracil derivative is prepared by condensing 5-fluorouracil with a halide of the formula: ##STR3## in the presence of a base. The 5-fluorouracils according to the invention show anti-tumor activity.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.