Process for the preparation of 4-chloro-5-alkoxycarbonyl-2-methoxy-pyrimidines
US4125720A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Apr 12, 1977 |
| Grant date | Nov 14, 1978 |
| Priority date | — |
| Expiry date | Apr 12, 1997 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D239/52
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Process for the preparation of a 4-chloro-5-alkoxycarbonyl-2-methoxy-pyrimidine of the formula: ##STR1## IN WHICH R.sub.1 is a lower alkyl radical with 1 to 4 carbon atoms, which comprises the following stages: A) condensation of a salt of O-methylisourea and an inorganic or organic acid, with an alkyl alkoxymethylenemalonate ##STR2## in an aqueous medium and in the presence of an excess of an alkali metal hydroxide, to form the corresponding salt of the 5-alkoxycarbonyl-4-hydroxy-2-methoxy-pyrimidine, and neutralization of the said salt by the addition of an inorganic or organic acid, in order to liberate this 5-alkoxycarbonyl-4-hydroxy-2-methoxy-pyrimidine, and ##STR3## B) bringing the latter compound, suspended in dimethylformamide, into contact with thionyl chloride, at room temperature, in order to form the corresponding 4-chloro-5-alkoxycarbonyl-2-methoxy-pyrimidine: ##STR4##
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.