Nortropine-carbazate derivatives
US4127576A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Nov 29, 1977 |
| Grant date | Nov 28, 1978 |
| Priority date | — |
| Expiry date | Nov 29, 1997 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P25/02
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention relates to novel nortropine-carbazate derivatives of the general formula (I), ##STR1## wherein R.sub.1 is C.sub.1-4 alkyl, phenyl or halophenyl group, PA1 R.sub.2 is hydrogen or a C.sub.1-4 alkyl, hydroxy-C.sub.1-4 alkyl, C.sub.1-4 acyl, phenoxycarbonyl or C.sub.1-4 alkoxycarbonyl group, and PA1 R.sub.3 is hydrogen of a C.sub.1-4 alkyl or C.sub.1-4 acyl group, or PA1 R.sub.2 and R.sub.3 may form together a C.sub.1-10 alkylene group attached PA1 To the nitrogen atom with a double bond, as well as to pharmaceutically acceptable acid addition salts of said compounds. The above compounds are new and can be applied as narcosis potentiating agents. The compounds of the general formula (I) can be prepared by reacting a compound of the general formula (II), ##STR2## wherein R.sub.1 is as defined above and Q is halogen, C.sub.1-4 alkoxy or phenoxy, with a hydrazine compound of the general formula (III), ##STR3## wherein R.sub.2 and R.sub.3 are as defined above. According to another method a compound of the general formula (II), wherein R.sub.1 and Q are as defined above, is reacted with hydrazine or hydrazine hydrate, and the resulting compound of the general formula (I), wher…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.