Process for preparation of stable amorphous macrolide antibiotic solids
US4127647A · kind A · utility
22Cited by
1References
9Claims
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Assignee
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Key dates
| Filing date | Oct 14, 1977 |
| Grant date | Nov 28, 1978 |
| Priority date | — |
| Expiry date | Oct 14, 1997 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K47/38
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Amorphous solids of macrolide antibiotics which are stable with the passage of time are prepared by dissolving a macrolide antibiotic and a cellulose polymer selected from the group consisting of ethyl cellulose, hydroxypropyl cellulose and hydroxypropylmethyl cellulose as a stabilizing substance in a volatile organic solvent selected from the group consisting of dichloromethane, 1,1,1-trichloroethane and chloroform and spray drying the resulting solution.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.