2-Formamido phenylguanidines and processes for their preparation and use

US4127670A · kind A · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Hartmund Wollweber · Wuppertal, DE
• Heinrich Kolling · Haan, DE
• Herbert Thomas

Key dates

• Filing date: Feb 22, 1977
• Grant date: Nov 28, 1978
• Expiry date: Feb 22, 1997

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C279/24
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

N-(2-formamidophenyl)-N',N"-bis-carbonylguanidines bearing an optionally substituted phenoxy, phenylthio, phenylsulfinyl or phenylsulfonyl group in the 4- or 5-position of the 2-(formamido)-phenyl group are anthelminetic agents. The compounds, of which N-(2-formamido-4-phenylthiophenyl)-N',N"-bis-carbomethoxyguanidine is a typical example, are prepared through the reaction of isothiourea-S-alkyl ether and an appropriately substituted 2-aminoformanilide.