Aminoeverninomicin and derivatives thereof

US4129720A · kind A · utility

Assignee

• SCHERING CORPORATION · US

Inventors

• Ashit K. Ganguly · Upper Montclair, US
• Viyyoor M. Girijavallabhan · Parsippany, US
• Olga Sarre · Verona, US
• Hans Reimann · Ebenhausen, DE

Key dates

• Filing date: Sep 16, 1977
• Grant date: Dec 12, 1978
• Expiry date: Sep 16, 1997

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P31/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Everninomicin B, C or D may be converted to amino derivatives by reductive means. The amino derivatives may, subsequently, be converted to novel N-acyl, N-alkyl or N,N-dialkyl derivatives. Alternatively, everninomicins B, C or D may be converted to N-acyl-N-hydroxylamino derivatives also by reductive means. The derivatives so-produced and the non-toxic pharmaceutically acceptable cationic salts thereof are novel and are antibacterial agents.