Process for converting 3-methylene cephalosporins to 3-heterothiomethyl cephalosporins
US4129731A · kind A · utility
1Cited by
11References
10Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Dec 8, 1976 |
| Grant date | Dec 12, 1978 |
| Priority date | — |
| Expiry date | Dec 8, 1996 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02P20/55
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
This invention relates to the preparation of 3-heterothiomethyl cephalosporanic acid esters of the formula ##STR1## by treating a 3-methylene cephalosporin of the formula ##STR2## with a compound of the formula EQU HETERO-S-S-hetero or X-S-hetero in the presence of a base wherein R is a readily removable ester group, R.sub.1 is in the .alpha.-configuration and is hydrogen or methoxy, and X is a leaving group. The resulting 3-heterothio cephalosporin esters are treated according to known methods to remove the ester protecting group and yield the corresponding free acids which have antibacterial activity.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.