Urapidil/furosemide compounds, compositions and use

US4131678A · kind A · utility

Assignee

• Byk Gulden Lomberg Chemische Fabrik GmbH · DE

Inventors

• Hermann Amschler · Radolfzell, DE
• Kurt Klemm
• Gerhard Ludwig · Haltern, DE

Key dates

• Filing date: Feb 9, 1977
• Grant date: Dec 26, 1978
• Expiry date: Feb 9, 1997

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D307/52
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A combination of urapidil and furosemide, e.g., in the form of an acid-addition salt, in the form of a physical admixture or in the form of two distinct components collectively constitutes an effective active ingredient in the treatment of hypertension. The combination is advantageously incorporated in a standard dosage form and administered by various routes to mammals afflicted with high blood pressure. By combining furosemide with urapidil on one of the noted forms, the maximum hypotensive activity of urapidil is increased, while the side effects and toxicity of urapidil are reduced.