Hypotensive sulphonamidopiperidyl indoles

US4131680A · kind A · utility

Assignee

• John Wyeth & Brother Limited · GB

Inventors

• John L. Archibald
• John Lambert Jackson

Key dates

• Filing date: Sep 23, 1976
• Grant date: Dec 26, 1978
• Expiry date: Sep 23, 1996

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D211/58
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

This invention relates to compounds having the general formula: ##STR1## WHEREIN W represents a phenyl or indolyl radical, either of which radicals may be unsubstituted or substituted by halogen, lower alkyl, lower alkoxy or hydroxy. A represents a lower alkylene radical, an oxo lower alkylene radical or a hydroxy lower alkylene radical; R represents a phenyl radical optionally substituted by halogen, lower alkyl, lower alkoxy or hydroxy, a cycloalkyl radical of 5 to 7 carbon atoms or a lower alkyl radical; R.sup.1 represents hydrogen or a lower alkyl radical or a pharmaceutically acceptable acid addition or quaternary ammonium salt thereof; which possess hypotensive activity.