Hypoglycaemically and hypolipidaemically effective n-substituted carboxylic acid amides

US4136197A · kind A · utility

Assignee

• Boehringer Mannheim GmbH · DE

Inventors

• Manfred Hubner · Ludwigshafen am Rhein, DE
• Ruth Heerdt · Mannheim, DE
• Elmar Bosies · Weinheim, DE
• Hans-Frieder Kuhnle · Weinheim, DE
• Felix Helmut Schmidt

Key dates

• Filing date: Apr 6, 1977
• Grant date: Jan 23, 1979
• Expiry date: Apr 6, 1997

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2603/18
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

An N-substituted carboxylic acid amide of the formula ##STR1## wherein A is a valency bond or an oxygen or sulphur atom or a methylene, ethylene, vinylene, ethyleneoxa or ethylenethia radical, PA1 V is a trivalent hydrocarbon radical containing up to 4 carbon atoms, PA1 R.sub.1 and R.sub.2 each independently is hydrogen, a halogen atom, a hydroxyl group or an alkyl or alkoxy radical, PA1 R.sub.3 is hydrogen, a hydroxyl group or an alkoxy radical, PA1 Y is an alkylene radical containing up to 3 carbon atoms, PA1 X is a valency bond or a divalent aliphatic hydrocarbon radical containing up to 6 carbon atoms, and PA1 D is a hydroxymethyl, formyl, free or esterified carboxyl or an N-substituted carbamoyl radical, or a physiologically compatible salt thereof, characterized by hypoglycaemic and hypolipidaemic activity.