Novel chromogenic enzyme substrates

US4137225A · kind A · utility

Assignee

• AB Kabi · SE

Inventors

• Bo T. af Ekenstam
• Leif E. Aurell
• Karl G. Claeson
• Birgitta Karlsson · Timrå, SE
• Stig I. Gustavsson · Mölndal, SE
• Gun A. Olausson · Mölndal, SE

Key dates

• Filing date: Mar 20, 1978
• Grant date: Jan 30, 1979
• Expiry date: Mar 20, 1998

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S530/802
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

Diagnostically active chromogenic substrate with good stability and high specificity to serine proteases having the formula: H-D-A.sub.1 -A.sub.2 -A.sub.3 -NH-R or salts thereof, wherein A.sub.1 is Gly, Ala, Val, Leu, Ile, Pip, Pro, or Aze; A.sub.2 is Gly, Ala, Val, Leu, Ile, Pip, Pro, Aze, or Phe; A.sub.3 is Arg, Lys, or Orn, and R is a chromophoric group.