Method for the production of maytansinoids
US4137230A · kind A · utility
181Cited by
1References
11Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Mar 15, 1978 |
| Grant date | Jan 30, 1979 |
| Priority date | — |
| Expiry date | Mar 15, 1998 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D498/18
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Maytansinoid compounds are produced by contacting in the presence of a carbodiimide the compound maytansinol ##STR1## with an acid of the formula: ##STR2## wherein R is lower alkyl, to yield the desired maytansinoids HAVING THE RESULTANT FORMULA: ##STR3## wherein R is lower alkyl. The maytansinoids (I) are both antifungal agents and also antitumor agents. The D-form (with respect to assymetry at the 2'-position) of the maytansinoids (I) represents a new class of compounds having antifungal and antitumor properties.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.