N-(phenylalkylamino-alkyl)-dihydroisoquinolinones, pharmaceutical compositions and methods employing them

US4137318A · kind A · utility

Assignee

• Boehringer Ingelheim GmbH · DE

Inventors

• Wolfgang Eberlein · Biberach, DE
• Joachim Heider · Warthausen, DE
• Volkhard Austel · Biberach, DE
• Jurgen Dammgen · Sulmingen, DE
• Rudolf Kadatz · Zell am Harmersbach, DE

Key dates

• Filing date: Aug 22, 1977
• Grant date: Jan 30, 1979
• Expiry date: Aug 22, 1997

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D217/26
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds of the formula ##STR1## wherein R.sub.1, R.sub.2 and R.sub.6, which may be identical to or different from each other, are each hydrogen or lower alkyl; PA1 R.sub.3 is lower alkoxy; PA1 R.sub.4 is lower alkoxy or, together with R.sub.3, methylenedioxy or ethylenedioxy; PA1 R.sub.5 is hydrogen, lower alkyl or benzyl; PA1 R.sub.7 is hydrogen or lower alkoxy; PA1 R.sub.8 is hydrogen, lower alkoxy or, together with R.sub.7, methylenedioxy or ethylenedioxy; PA1 M is 1 or 2; and PA1 N is 2 or 3; And non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as their salts are useful as antihypertensives and heart rate reducers.