Patent · US Expired

Purifying and isolating method for hepatitis virus to use in preparing vaccine

US4138287A · kind A · utility

24Cited by

3References

10Claims

0Family size

Assignee

AB Kabi · SE

Inventors

Lars Andersson · Knivsta, SE
Gudrun M. Einarsson · Uppsala, SE
Lennart P. Kaplan · Uppsala, SE

Key dates

Filing date	Mar 15, 1977
Grant date	Feb 6, 1979
Priority date	—
Expiry date	Mar 15, 1997

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12N2730/10122
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Hepatitis B virus (detectable as its surface antigen HB.sub.s Ag) is produced in a purification preferably suitable for use in preparing a hepatitis vaccine, by contacting a crude biological starting material containing hepatitis B virus with a water-insoluble cross-linked sulfated polysaccharide gel matrix adsorbing agent to adsorb the hepatitis B virus thereon and then desorbing that virus therefrom by treating that hepatitis B virus carrying adsorbent with a desorbing agent.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.