Plaque dispersing enzymes as oral therapeutic agents by molecular alteration
US4138476A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Aug 3, 1977 |
| Grant date | Feb 6, 1979 |
| Priority date | — |
| Expiry date | Aug 3, 1997 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61Q11/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
An oral therapeutic substance is formed by modifying a plaque-dispersing enzyme to control and reduce the occurrence of dental caries and periodontal diseases. In one embodiment, the modification is performed by introducing a suitable complexing reagent in combination with carrier and plaque-dispersing glucanohydrolase molecules to molecularly alter the glucanohydrolase. The modification, while having insignificant effects on the catalytic activity of the enzyme, will increase the binding capability of the enzyme to substances of which the tooth surface is formed. The activity of the enzyme on the tooth surface will therefore be maintained for longer periods of time to combat plaque build-up.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.