Analgesic compositions containing 1,2-dihydro-2-oxoquinol-4-ylpropionic acid derivatives
US4138490A · kind A · utility
8Cited by
1References
7Claims
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Assignee
Inventors
Key dates
| Filing date | Sep 12, 1977 |
| Grant date | Feb 6, 1979 |
| Priority date | — |
| Expiry date | Sep 12, 1997 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D215/38
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Novel 1,2-dihydro-2-oxoquinol-4-ylalkanoic acid derivatives bearing a variety of substituents on the quinoline nucleus but including, at position 1, an aromatic radical linked directly or through a C.sub.1-4 -alkylene or a C.sub.2-4 -alkenylene radical. Representative compounds of the invention are 1-(3,4-dichlorobenzyl)-3-methyl-1,2-dihydro-2-oxoquinol-4-ylacetic acid and .alpha.-(1-benzyl-1,2-dihydro-2-oxoquinol-4-yl)propionic acid. The compounds possess anti-inflammatory or analgesic properties, or are inhibitors of the enzyme aldose reductase.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.