Adenosine deaminase resistant antiviral purine nucleosides and method of preparation
US4138562A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Feb 9, 1977 |
| Grant date | Feb 6, 1979 |
| Priority date | — |
| Expiry date | Feb 9, 1997 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07F9/65616
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The preparation of (.+-.)-9-[.alpha.-(2.alpha.,3.beta.-dihydroxy-4.alpha.-(hydroxymethyl) cyclopentyl)]-6-substituted purines: ##STR1## and (.+-.)-3-[.alpha.-(2.alpha., 3.beta.-dihydroxy-4.alpha.-(hydroxymethyl)cyclopentyl)]-7-substituted-v-tr iazolo[4,5d]pyrimidines: ##STR2## and their derivatives wherein R is amino, mercapto, methylmercapto, hydroxy, halogen, or substituted amino: ##STR3## wherein R' and R" may be the same or different and are of hydrogen, methyl, ethyl, propyl or phenyl. The preparation of the single intermediate from which either of these series of compounds may be synthesized is also disclosed. The compounds exhibit antiviral and antitumor activity.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.