Water-soluble, non-ionizing, radiopaque compounds and contrast compositions containing the same
US4139605A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Feb 27, 1978 |
| Grant date | Feb 13, 1979 |
| Priority date | — |
| Expiry date | Feb 27, 1998 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C233/12
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
.alpha., .omega.-BIS-[5-(DIHYDROXYALKYL) AMINOCARBONYL-3-HYDROXYACYL-AMINO-2,4,6-TRIIODO-BENZOYL-AMINO]-OXAALKANE COMPOUNDS OF THE FORMULA ##STR1## wherein R.sub.1 is ##STR2## R and R' are hydrogen or methyl, R.sub.2 is dihydroxyalkyl having 3 or 4 carbon atoms, PA1 N is 2 or 3, PA1 M is an integer between 1 and 5, and PA1 N(m+1) is an integer between 4 and 12, Are readily soluble in water to yield injectable radiopaque contrast compositions which are well tolerated and stable. The compounds are prepared in good yields by reacting a reactive derivative of a 5-(di-hydroxyalkyl)aminocarbonyl-3-acyloxyacylamino-2,4,6-triiodo-benzoic acid with an .alpha.,.omega.-diamino-oxaalkane of the formula EQU R--NH--C.sub.n H.sub.2n --(O--C.sub.n H.sub.2n)--NH--R.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.