Amino-spiro[oxa(or thia)cycloalkane-penam]-carboxylic acid derivatives
US4139628A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jan 16, 1978 |
| Grant date | Feb 13, 1979 |
| Priority date | — |
| Expiry date | Jan 16, 1998 |
Classification
- Technology area (CPC B)Performing Operations; Transporting
- CPC primaryB60W2710/027
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Amino-spiro[oxa(or thia)cycloalkane-penam]-carboxylic acid derivatives having the formula ##STR1## WHEREIN X is a sulfur or oxygen atom or the sulfinyl group, n is 1 or 2, m is 1 or 2, R.sub.1 is hydrogen, R.sub.2 is one of the radicals known in the chemistry of the penicillins, preferably 2-phenylacetyl, 2-amino-2-phenylacetyl, 5-methyl-3-phenyl-4-isoxazolecarbonyl or 2,6-dimethoxybenzoyl, or R.sub.1 and R.sub.2 together represent a bivalent radical R.sub.3, preferably (hexahydro-1H-azepin-1-yl)methylene and their therapeutically acceptable non-toxic salts and process for preparing the same. These compounds have valuable antibacterial properties and are useful as therapeutic agents in the treatment of infectious diseases caused by Gram-positive and Gram-negative bacteria.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.