Aqueous collagen composition
US4140537A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Nov 24, 1976 |
| Grant date | Feb 20, 1979 |
| Priority date | — |
| Expiry date | Nov 24, 1996 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61F2310/00365
- WIPO fieldChemical engineering
- WIPO sectorChemistry
Abstract
The naturally occurring collagen is modified by removal of certain terminal peptide chains, which are described as telopeptides. The modified collagen, so derived, is described as atelopeptide collagen. Native collagen is immunogenic, while atelopeptide collagen is nonimmunogenic or possessed of a negligibly low level of immunogenicity. The collagen in solution is then treated according to a specific regimen under conditions whereby the collagen slowly separates from solution while exposed to mild shear forces. This procedure results in the formation of a fibrous precipitate composed of regularly ordered fibers of collagen possessed of a ropelike structure. These resulting aggregates are referred to as native fibrous micropolymers (NFM). Once the regimen or procedure is completed, and the fiber mass has been formed, the fibrous micropolymers may be freed of salt, taken up in a different solution or modified. For example, cross-links may then be introduced to stabilize the fibers. The products find wide use as packing, membranes, fibers, bags, supports, integuments, and are especially suitable for biologic implantation or application.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.